I did this trip almost 2 years ago so thought I would just add my ideas which may (or may not!) help!
The Alcatraz trip is fantastic and well worth doing but, as has been said, don't wait until you get to SF. It books really quickly. It was one of my favourite things of the whole trip. The island was in sight of my balcony too at the Radisson so that was great.
If you want to go on the street cars (first night might be a good time to find your way around) - don't queue at the terminus just up from the hotel - you could be there an hour! Walk up the hill, one or two stops (follow the cables!) and get on one straight away! Far better.
Universal - I didn't go. It's a theme park. What can be so different? However, when the trip was on there were no plans in place for non-do-ers apart from going back to the hotel. There's not much to do in Sherman Oaks! This may of course have changed now.
Instead, a few of us got dropped off at the Food market in Beverley Hills. That was interesting and good to see but it got better when we went a few blocks up and had coffee at the Beverley Wilshire - in the place 'Pretty Woman' was set. The hotel is gorgeous and just having coffee there an experience not to be missed. After that we mooched around Rodeo Drive which again was a real experience, so much to see, then headed on back uptown (LA). In retrospect, the coach could have met us to take us back - worth asking about - but we used public transport. That was easy enough.
San Luis Obispo is a really lovely boho type town and well worth exploring. It's quite a few blocks walk from the hotel - which was really good - but far better choices to look around in town and to eat in than the few restaurants around the hotel. I would have rather stayed here for another night than Palm Springs later in the trip tbh.
Anyway, have a fab time. Any questions - please ask away.